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Kim Etherington Trauma Drug Misuse and - world-movies.ru
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Kim Etherington Trauma, Drug Misuse and Transforming Identities

Kim Etherington Becoming a Reflexive Researcher - Using Our Selves in Research

Zhou Honghui Drug-Drug Interactions for Therapeutic Biologics


Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.

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David Emmett Understanding Street Drugs


This fully updated edition of the essential reference Understanding Drugs provides a complete overview of the key facts and core issues surrounding substance misuse. All commonly-used street drugs are covered, with quick reference guides, helpful diagrams and clear information on each drug's effects, methods of use, legal status, availability, treatment options and associated slang. This edition includes new sections on ketamine, `date-rape' drugs, and over-the-counter opiate-based drugs, and recent findings on the long-term effects of cannabis and its potential medicinal use, and discussion of the legalisation debate. This comprehensive handbook is an essential reference for teachers, social workers, youth workers, residential home managers, policy makers and parents, enabling readers to recognise drug misuse and confidently offer information and guidance. A companion volume, Understanding Drug Issues: A Photocopiable Resource Workbook is also available from Jessica Kingsley Publishers.

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Lu Chuang Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad


The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.

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Albert P. Li Transporters and Drug-Metabolizing Enzymes in Drug Toxicity


This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug metabolism in toxicity evaluation

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Michael J. Neal Medical Pharmacology at a Glance


The internationally best-selling Medical Pharmacology at a Glance is the ideal companion for all medical and healthcare students, providing a visual overview of pharmacology, and describing the basic principles of drug action, interaction, absorption, and excretion. Clear and accessible chapters organised around common diseases and conditions facilitate efficient clinical learning, and include references to drug classes and side effects, disease pathophysiology, prescribing guidelines, and more.  Now in its ninth edition, this leading guide has been thoroughly updated to reflect current guidelines and drug information. This edition features new and revised illustrations, additional pedagogical tools, and enhanced online content. Widely recognised as both the best introduction to medical pharmacology and the perfect revision tool for USMLE and pharmacology exams, this invaluable guide: Covers a wide range of drugs used to treat conditions such as hypertension, anaemias, cancer, and affective disorders Explains drug mechanisms and the principles of drug action Discusses practical topics including drug misuse, drug indications, and side effects Includes a companion website featuring online cases, flashcards, and a list of core drugs

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Binghe Wang Drug-Drug Interactions in Pharmaceutical Development


Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

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Lynn R Webster Avoiding Opioid Abuse While Managing Pain


This book was written to help all interested parties (eg, clinicians who treat pain, drug and medical-practice regulators, law-enforcement authorities and pharmacists) to sort out the clinical, regulatory, and ethical issues associated with the prescribing of opioid analgesics and to reduce the risk of medication misuse, abuse, and diversion.

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Andy Taylor Parental Substance Misuse and Child Welfare

Nick Heather Treatment Approaches for Alcohol and Drug Dependence


The first edition of this book was based upon the recommendations of the Quality Assurance in the Treatment of Drug Dependence Project, and provided a step-by-step-guide for therapists working with clients with alcohol or other drug dependency or misuse. Since publication in 1995 it has become well known for its easy-to-read style and wealth of practical resource materials. However, the evidence in the field has moved forward in the last eight years, creating a need for an updated edition. Retaining the trademark easy-to-use, up-to-date style, the Second Edition offers new chapters on pharmacotherapies, case management, young people, and dual diagnosis. Other chapters have been updated to reflect the latest research findings and current practice, and the practice sheets and client handouts are made available online for downloading and customization by therapists.

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Barratt Michael J. Drug Repositioning. Bringing New Life to Shelved Assets and Existing Drugs


The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

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Ekins Sean Drug Efficacy, Safety, and Biologics Discovery. Emerging Technologies and Tools


Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

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Johnson Douglas S. Modern Drug Synthesis


Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

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Dale Gieringer, PhD California NORML Guide to Drug Testing


California NORML Guide to Drug Testing is the authorative and indispensable guide to: dealing with drug testing on short notice; drug test detection times; medical marijuana and drug tests; drug tests and DUI, and what’s wrong with drug testing. Paul Armentano, deputy director of NORML writes, “This booklet arms cannabis consumers with the knowledge they need to protect themselves from discrimination in the workplace and provides activists with the information they need to effectively lobby against these pernicious policies.”

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Buchwald Peter Retrometabolic Drug Design and Targeting


Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

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Группа авторов Music, Music Therapy and Trauma


Music communicates where words fail, and music therapy has been proven to connect with those who were thought to be unreachable, making it an ideal medium for working with those who have suffered psychological trauma. Music, Music Therapy and Trauma addresses the need for an exploration of current thinking on music and trauma. With chapters written by many of today's leading specialists in this area, music and trauma is approached from a wide range of perspectives, with contributions on the following: * neurology of trauma and music; * music and trauma in general; * social and cultural perspectives on trauma; * contextualising contemporary classical music and conflict; * music and trauma in areas where there is war, community unrest and violence (Northern Ireland, Bosnia-Herzegovina, South Africa); * music, trauma and early development. Including specific examples and case studies, this book addresses the growing interest in the effects of trauma and how music therapy can provide a way through this complex process.

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Lee Turner Trauma Rules 2


Trauma Rules 2 retains its lively and fun presentation to help you remember the essential principles of trauma care and feel confident about handling and treating patients appropriately in the first hours of injury. Thoroughly expanded and updated, and now including military trauma rules, the second edition of this popular pocket book now offers: 70 easy-to-memorize rules covering the important aspects of trauma care clear, authoritative explanations and instructive illustrations the three principal stages of trauma management: approach to the patient, initial assessment and resuscitation, and investigation and definitive care Trauma Rules 2 is compiled especially for those dealing with the immediate and early management of the severely injured patient.

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Dimitri Semizarov Genomics in Drug Discovery and Development


Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.

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Hugo Kubinyi Molecular Drug Properties


This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, electronic properties and conformation.

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